About the Scientist
Training
| Degree: |
Ph.D. - Pharmacy |
| Institution: |
University of Sydney, Australia |
| Year: |
2003 |
|
| Degree: |
Grad. Dip. Sci. - Pharmacy |
| Institution: |
University of Sydney, Australia |
| Year: |
1999 |
|
| Degree: |
B.Sc. - Pharmacy |
| Institution: |
Guiyang Medical College, China |
| Year: |
1985 |
|
Current Position
| Position: |
Research Associate |
| Supervisors: |
Dr. Frank S. Abbott & Dr. Thomas Chang |
|
|
Scholarships + Awards
| Name: |
MSFHR Post-doctoral Fellowship |
| Year: |
2004 |
|
|
| Name: |
Rx & D Post-doctoral Fellowship |
| Year: |
2004 |
|
|
| Name: |
Elizabeth Wunsch Postgraduate Research Scholarship |
| Year: |
1999 |
|
|
About The Research
Role Of Oxidative Stress In Valproic Acid-Induced Hepatotoxicity. Many patients with epilepsy take valproic acid to control seizures. Although the drug is generally safe, it has been associated with a rare but irreversible liver failure that can be fatal particularly in children. It’s not clear how valproic acid causes liver failure. My research project is to identify factors involved in the development of liver toxicity by this drug and to determine how to prevent this serious side effect. The experiments will be conducted rat and human hepatocytes as well as in young epileptic patients who are receiving valproic acid.
Publications + Presentations
| Selected Publications |
- Teng XW and Davies NM (2004) High-performance liquid chromatographic analysis of a selective cyclooxygenase-1 inhibitor SC-560 in rat serum: application to pharmacokinetic studies. J Pharm Biomed Anal 35:1143-7.
- Roupe K, Teng XW, Fu X, Meadows GG and Davies NM (2004) Determination of piceatannol in rat serum and liver microsomes: pharmacokinetics and phase I and II biotransformation. Biomed Chromatogr 18:486-91.
- Teng XW, Wang SW and Davies NM (2003) Stereospecific high-performance liquid chromatographic analysis of ibuprofen in rat serum. J Chromatogr B Analyt Technol Biomed Life Sci 796:225-31.
- Teng XW, Abu-Mellal AK and Davies NM (2003) Formulation dependent pharmacokinetics, bioavailability and renal toxicity of a selective cyclooxygenase-1 inhibitor SC-560 in the rat. J Pharm Pharm Sci 6:205-10.
- Teng XW, Cutler DC and Davies NM (2003) Degradation kinetics of mometasone furoate in aqueous systems. Int J Pharm 259:129-41.
- Teng XW, Cutler DJ and Davies NM (2003) Kinetics of metabolism and degradation of mometasone furoate in rat biological fluids and tissues. J Pharm Pharmacol 55:617-30.
- Teng XW, Cutler DJ and Davies NM (2003) Mometasone furoate degradation and metabolism in human biological fluids and tissues. Biopharm Drug Dispos 24:321-33.
- Davies NM, Teng XW and Skjodt NM (2003) Pharmacokinetics of rofecoxib: a specific cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet 42:545-56.
- Teng XW, Foe K, Brown KF, Cutler DJ and Davies NM (2001) High-performance liquid chromatographic analysis of mometasone furoate and its degradation products: application to in vitro degradation studies. J Pharm Biomed Anal 26:313-9.
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