Stoyan Karagiozov

E-mail:	stoyankk@interchange.ubc.ca
Phone:	604-822-7730

Degree:	Ph.D in Medicinal Chemistry
Institution:	Medical University of Sofia, Bulgaria
Year:	1987

Position:	Research Associate

Design of synthetic routes for the preparation of a variety of VPA analogues and related metabolites for QSAR studies.

Selective introduction of fluorine into organic molecules; preparation of fluorine-containing building blocks and their synthetic application.

Application of new Horner-Emmons reagents for synthesis of stereoselective olefins as potentially anticonvulsant candidates.

Preparation of multicoupling reagents as a valuable tool for synthesis of complex molecules.

Selected Publications

Tong, V., Teng, X.W., Karagiozov, S, Chang, T. K .H, and Abbott F. S., Valproic acid glucuronidation is associated with increases in 15-F2t-Isoprostane in rats, Free Radical Biology and Medicine, 38, 1471-1483 (2005).
Karagiozov, S. K., Abbott, F. S., Practical Stereoselective Synthesis of (2E)- and (2Z)-4-Cycloalkylidenebut-2-enoic Acids, Synthetic Communications, 34, 5, 871-888 (2004).
S. K. Karagiozov, I. C. Ivanov, B. Iliev, N-{2-[(2-Oxo-2H-chromen-4-yl)amino]ethyl} acetamidine, Molecules 1999, M126.
I. C. Ivanov, S. K. Karagiozov, S. V. Alexandrova, Synthesis of 5H-[1]Benzopyrano[4,3-d]pyrimidine-5-one, C. R. Acad. Bulg. Sci. 51 (1), (1998).
I. C. Ivanov, S. K. Karagiozov, Two Methods for the Preparation of 3-Dialkylamino-methyl Derivatives (Mannich Bases) of 4-Aminocoumarin: A New Type of Intramolecular Hydride Transfer, Synthesis (6), 633-634 (1995).
D. Heber, I. C. Ivanov, S. K. Karagiozov, [1]Benzopyrano[4,3-d]pyridine-5-ones. An Unusual Pyridine Ring closure, J. Heterocycl. Chem. 32, 505-509 (1995).
I. C. Ivanov, S. K. Karagiozov, M. F. Simeonov, A Facile Synthesis of [1]Benzopyrano[4,3-b]pyridin-5-ones, Libiegs Ann. Chem. 203-207 (1992).
I. C. Ivanov, S. K. Karagiosov, I. Manolov, Synthesis of 4-(Monoalkylamino) coumarins, Arch. Pharm. (Weinheim) 324, 61 (1991).
I. C. Ivanov, S. K. Karagiozov, P. B. Sulay, One-flask Pyridylethylation of Amines by 2-(2-Pyridyl)-ethanol, Arch. Pharm. (Weinheim) 322, 181 (1989).

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