Rishi Somvanshi

About the Scientist

E-mail:	rishiks@mail.ubc.ca
Phone:	604-827-3672
Fax:	604-822-3035

Training

Degree:	Ph.D., Biophysics
Institution:	All India Institute of Medical Sciences (AIIMS)
Year:	2008

Degree:	M.Sc., Biotechnology
Institution:	Jiwaji University
Year:	2003

Previous Position

Position:	Senior Research Fellow, Biophysics
Research Group:	Biophysics, All India Institute of Medical Sciences, New Delhi
Period:	Jan 2004 - May 2007

Previous Positions

Position:	Postdoctoral Fellow
Institution:	UBC, Faculty of Pharmaceutical Sciences
Supervisor:	Dr. U. Kumar

Current Position

Position:	Research Associate
Supervisors:	Dr. U. Kumar

Scholarships + Awards

Name:	Senior Research Fellowship
Organization:	Council for Scientific and Industrial Research (CSIR), New Delhi, India
Period:	Jan 2007 - Oct 2007

Name:	Senior Research Fellowship
Organization:	Indian Council for Medical Research (ICMR), New Delhi, India
Period:	Jan 2006 - Dec 2006

Name:	Senior Research Fellowship
Organization:	Department of Science and Technology (DST), New Delhi, India
Period:	Jan 2005 - Dec 2005

Name:	Institute Fellowship
Organization:	All India Institute of Medical Sciences (AIIMS), New Delhi, India
Period:	Jan 2004 - Dec 2004

About The Research

Functional Interactions between Somatostatin Receptors (SSTR1-5) and Opioid Receptors (µ, δ and κ)

Functional Interactions between Somatostatin Receptors (SSTR1-5) and β-Adrenergic Receptors ( β1-AR and β2-AR)

Publications + Presentations

Selected Publications

Somvanshi R. K., Qiu X and Kumar U. (2012) “Role of Somatostatin in Adrenergic Receptors mediated signaling, hypertrophy and Apoptosis in H9c2 cells.” International J of Cardiology (In Press)
Somvanshi R. K., Kumar U. (2012) “Pathophysiological Implications of Somatostatin Receptors Dimerization” Pharmaceuticals (In Press)
Somvanshi R. K. Chaudhari N., War S.A., Qiu X., Kumar U. (2011) “Heterodimerization of β2 Adrenergic Receptor and Somatostatin Receptor 5: Implications in Modulation of signaling Pathway.” Journal of Molecular Signaling, 6: 9
Somvanshi R. K., War S.A, Chaudhari N., Qiu X., Kumar U. (2011) “Heterodimerization of β1 Adrenergic Receptor and Somatostatin Receptor 5: Implications in Modulation of signaling Pathway.” Cellular Signaling, 23(5): 794-811.
War S.A., Somvanshi R. K., Kumar, U. (2009) “Somatostatin receptor-3 mediated regulation of cell signaling and apoptosis” Submitted paper.
Kharmate, G., Rajput, P. S., Watt H. A., Somvanshi R. K., Kumar, U. (2011) "Modulation of Epidermal Growth Factor Mediated Signaling Pathways by Somatostatin Receptors: Implication in the Pathophysiology of Breast Cancer.” Endocrinology, 152(3): 931-45
Somvanshi, R. K., Billova S., Rajput P.S, Kharmate G. and Kumar U. (2009) “C-tail mediated modulation of somatostatin receptor type-4 homo-and heterodimerization and signaling.” Cellular Signalling 21(9):1396-414.
Rajput, P. S., Kharmate G., Somvanshi, R. K., Kumar, U. (2009) “Colocalization of Dopamine Receptor Subtypes with Dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brain.” Neuroscience Res. 65(1):53-63.
Somvanshi, R. K., Singh, A. K., Saxena, M., Mishra, B., Dey, S. (2008) “Development of a novel peptide inhibitor of Lipoxygenase based on biochemical and BIAcore evidences.” Biochim Biophys Acta., 1784(11): 1812-1817.
Somvanshi, R. K., Subashini, R., Dhanasekaran, V., Arulprakash, G., Das, S., Dey, S. (2008) “Synthesis, Crystal Structure, Cytotoxic and Apoptotic Activity of 2,4-Dichloro-6-methylquinoline on Human Oral Carcinoma Cell Line.” J. Chem. Cryst., 38, 381-386.
Somvanshi, R. K., Kumar, A., Kant, S., Gupta, D., Singh, S. B., Das, U., Srinivasan, A., Singh, T. P., Dey, S. (2007) “Surface plasmon resonance studies and biochemical evaluation of a potent peptide inhibitor against cyclooxygenase-2 as an anti-inflammatory agent.” Biochem. Biophy. Res. Com., 361, 37-42.
Singh, N., Somvanshi, R. K., Sharma, S., Dey, S., Kaur, P., Singh, T. P. (2007) “Structural elements of ligand recognition site in secretory phospho-lipase A2 and structure-based design of specific inhibitors.” Curr. Top. Med. Chem., 7, 757-764. Review
Somvanshi, R. K., Goel, V. K., Dey, S., Singh, T. P. (2005) “Design of peptides with α,β-dehydro-residues: Synthesis and crystal structure of a tetrapeptide Boc-Ala-ΔPhe-ΔPhe-Phe-OCH3.” J. Chem. Cryst., 35, 761-768.
Goel, V. K., Somvanshi, R. K., Dey, S., Singh, T. P. (2005) “Effects of branched beta-carbon dehydro-residues on peptide conformations: syntheses, crystal structures and molecular conformations of two tetrapeptides: (a) N-(benzyloxycarbonyl)-DeltaVal-Leu-DeltaPhe-Leu-OCH3 and (b) N-(benzyloxycarbonyl)-DeltaIle-Ala-DeltaPhe-Ala-OCH3.” J. Pept. Res., 66, 68-74.
Singh, N., Jabeen, T., Somvanshi, R. K., Sharma, S., Dey, S., Singh, T. P. (2004) “Phospholipase A2 as a target protein for nonsteroidal anti-inflammatory drugs (NSAIDS): crystal structure of the complex formed between phospholipase A2 and oxyphenbutazone at 1.6 A resolution.” Biochemistry 43, 14577- 83.

Selected Abstracts

Somvanshi R. K., Chaudhari N., Kharmate G., Bonnett J., Rajput P.S., War S. A., Qiu X., Cairns B.E. and Kumar U. (2011) Heterodimerization between Somatostatin Receptor-4 and δ-Opioid Receptor Modulates Signaling Pathways Mediating Analgesic Responses. Pain Research and Management, 16(2) 124.
Somvanshi R.K. Qiu, X., Kumar U. (2011) Role of Somatostatin in Modulation of β-Adrenergic Receptor Mediated Downstream Signaling Pathways in H9c2 Cells. Endocrine Reviews, 32, P1-171.
Somvanshi R. K., War S.A., Chaudhari N., Kharmate G., Rajput P.S., Bakshi D., Qiu X. and Kumar U. (2010) SSTR5 and β1AR blocks SST mediated inhibition of cAMP and signaling in receptor specific manner. The Journal of Heart Disease, 7(1), 115.
Somvanshi R. K., War S.A., Chaudhari N., Kharmate G., Rajput P.S., Bakshi D., Qiu X. and Kumar U. (2010) Modulation of apoptotic and calcineurin-mediated NFAT dephosphorylation in cells coexpressing SSTR5 and β2AR. The Journal of Heart Disease, 7(1), 116.
Somvanshi R. K., War S.A., Chaudhari N., Kharmate G., Rajput P.S., Bakshi D., Qiu X. and Kumar U. (2010) The Presence of Somatostatin Receptor 5 Modulates β1-Adrenergic Receptor Mediated Signaling Pathways. Endocrine Reviews, S1, 31(3): S179.
Somvanshi R. K., War S.A., Chaudhari N., Kharmate G., Rajput P.S., Bakshi D., Qiu X. and Kumar U., Somatostatin Receptor 5 and β2-Adrenergic Receptor Crosstalk Modulates Intracellular Signaling Endocrine Reviews, S1, 31(3): S180.
Somvanshi R.K. Kumar U. (2009) “C-tail mediated modulation of human somatostatin receptor type-4 (hSSTR4) homo-and heterodimerization, receptor internalization and cell signaling.” Can. J. Clin. Pharmacol., Volume 16 (2), e314
Somvanshi, R. K., Singh, N., Sharma, S., Dey, S., Singh, T. P. (2006) “Design of Specific Anti-inflammatory Agents Using Structure-Based Approach: Crystal structure of complex formed between Phospholipase A2 and Tetrapeptide Inhibitor Dehydro Val-Ala-Arg-Ser.” Inflammation Res., Vol. 55. Sup. 2; S 124.
Dey, S., Somvanshi, R. K., Kumar, A., Sharma, S., Singh, T. P. (2006) “Structure-based Rational Drug design against Inflammation, Rheumatism and Arthritis.” Inflammation Res., 2006; Vol. 55. Sup. 2; S 106.
Somvanshi, R. K., Goel, V. K., Saxena, M., Dey, S., Singh, T. P. (2005) “Design of peptides with consecutive dehydro phenylalanine residues.” Eur. Biophy. Journal. Vol. 34; No.6; 829.
Somvanshi, R. K., Singh, N., Ethayathulla, A. S., Kumar, A., Sharma, S., Srinivasan, A., Dey, S., Singh, T. P. (2005) “Structure- based drug design with alpha, beta - dehydro - amino acid residues.” J. Pep. Sci., Vol. 12, Issue S1 557.
Somvanshi, R. K., Dey, S., Singh, T.P. (2005) “Effects of branched beta - carbon residues on conformations of peptides containing dehydro – residues.” J. Pep. Sci., Vol. 12, Issue S1: 492.

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