About the Principal Investigator
Training
| Degree: |
Ph.D. |
| Institution: |
University of Toronto |
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| Degree: |
M.Sc. |
| Institution: |
University of Toronto |
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| Degree: |
B.Sc. |
| Institution: |
University of Toronto |
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Previous Positions
| Position: |
Postdoctoral Fellow |
| Institution: |
University of California, Berkeley |
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Current Position
| Position: |
Assistant Professor |
| Institution: |
Pharmaceutical Sciences |
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| Position: |
Affiliated Research Scientist |
| Institution: |
BC Cancer Agency |
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| Position: |
Associate Member |
| Institution: |
Genetics Graduate Program |
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Major Awards
| Name: |
Canada Research Chair in Genome Maintenance |
| Name: |
MSFHR Scholar |
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Links
About the Lab
My laboratory investigates mechanisms responsible for the gross structural maintenance of the genome, the role of telomeres and telomerase in preventing chromosome erosion, and the cellular pathways that respond to DNA damage. Most cancers and premature aging syndromes share an observable loss of genome integrity. Our long-term goal is to discover genetic and pharmacological means to control cellular changes that affect stable genome maintenance.
Training Environment
Our laboratory is home to a diverse group of students and science professionals. We believe that students should receive hands-on training in the laboratory and be in an environment that develops the analytical and creative skills that are necessary for academic success. In turn, we expect those who join our laboratory to genuinely enjoy the process of scientific discovery and to contribute intellectually to the collective success of the group. In addition to weekly laboratory meetings and journal discussions, members of the laboratory are expected to present their work at national and international scientific meetings.
Projects
Refer to the lab website.
Selected Publications
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Wong JMY, Kusdra L and Collins K. Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat Cell Biol. 4(9):731-6 (2002).
- Wong JMY and Collins K. Telomere maintenance and disease. Lancet 362(9388):983-8 (2003).
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Lee SR, Wong JMY and Collins K. Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate. J Biol Chem. 278(52):52531-6 (2003).
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Wong JMY, Kyasa MJ, Hutchins L and Collins K. Telomerase RNA deficiency in peripheral blood mononuclear cells in X-linked dyskeratosis congenita. Hum Genet 115:448-55 (2004).
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Masutomi K, Possemato R, Wong JMY, Currier JL, Tothova Z, Manola JB, Ganesan S, Lansdorp PM, Collins K and Hahn WC. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci USA. 102(23):8222-7 (2005).
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Wong JMY and Collins K. Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita. Genes Dev. 20(20) 2848-58 (2006).
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Fleisig HB and Wong JM. Telomerase as a clinical target: current strategies and potential applications. Exp Gerontol. 42(1-2):102-12 (2007).
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Errington TM, Fu D, Wong JMY and Collins K. Disease-associated human telomerase RNA variants show loss of function for telomere synthesis without dominant-negative interference. Mol Cell Biol. 28(20):6510-20 (2008).
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Savage SA, Dokal I, Armanios M, Aubert G, Cowen EW, Domingo DL, Giri N, Greene MH, Orchard PJ, Tolar J, Tsilou J, Van Waes C, Wong JMY, Young NS, Alter BP. Dyskeratosis Congenita: The First NIH Clinical Research Workshop. Epub. Pediatric Blood and Cancer (2009).
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