Frank S. Abbott


About the Principal Investigator

E-mail: fabbott@interchange.ubc.ca
Phone: 604-822-2566
Fax: 604-822-3035

Training

Degree: BSP, Pharmacy (with Great Distinction)
Institution: University of Saskatchewan
Year: 1959
Degree: MSc, Medicinal Chemistry
Institution: University of Saskatchewan
Year: 1962
Degree: PhD, Medicinal Chemistry
Institution: Purdue University
Year: 1966

Current Position

Position: Professor and Dean Emeritus

Links

Research Interests

  • analytical method development
  • drug receptor interactions
  • drug discovery
  • drug metabolism, drug interactions
  • quantitative structure-activity-relationships-toxicological investigations of drugs and metabolites:

 

About The Research

Research Focus

Current research focus is on reactive metabolites and the production of reactive oxygen species as mechanisms of idiosyncratic drug toxicity.  This information is used in drug discovery to produce safer drugs.

Please note that I will not be taking any new graduate students at this time.

Current Projects

CIHR Valproic acid analogues: glutathione dependant metabolism and mechanisms of toxicity.
CIHR Proof of Principle Grant CNS-active valproate analogues with improved safety profiles.

Selected Publications

Selected Publications
  • Stoyan Karagiozov and Frank S. Abbott, “Practical Stereoselective Synthesis of (2E)- and (2Z)-4-Cycloalkyidenebut-2-enoic acids”, Synthetic Communications, 34, 871-888 (2004).
  • Vincent Tong, Xiao Wei Teng, Thomas K H Chang, and Frank S Abbott, “Valproic Acid I: Time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolites in rats”, Toxicological Sciences, 86, 427-435 (2005).
  • Vincent Tong, Xiao Wei Teng, Thomas K H Chang, and Frank S Abbott, “Valproic acid II: Effects on oxidative stress, mitochondrial membrane potential and cytotoxicity in glutathione-depleted rat hepatocytes”, Toxicological Sciences, 86, 436-443 (2005).
  • Aspasia Michoulas, Vincent Tong, Xiao Wei Teng, Thomas Chang, Frank Abbott and Kevin Farrell, “Oxidative stress in children receiving valproic acid”, J Pediatr, 149, 692-696 (2006).
  • Tony Kiang, Ping Ho, Reza Anari, Vincent Tong, Frank Abbott, and Thomas Chang, “Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype”, Toxicological Sciences, 94, 261-271 (2006).
  • Chang, T. K. and Abbott, F.S. “Oxidative stress as a mechanism of valproic acid-associated hepatotoxicity”, Drug Metab Rev 38, 627-639 (2006).
  • Andrew Numa, Frank Abbott, and Thomas Chang, “Effect of Ginkgo Biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9 *1/*1 genotype”, Can J Physiol Pharmacol 85, 848-855 (2007).

 

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