Name: Anand Deo

Title: Ph.D. Student

Supervisor: Dr. Stelvio Bandiera

Email: ananddeo@interchange.ubc.ca

Education:

Research Project:

CYP Mediated Regulation of Bile Acids. Bile acids play a significant role in the digestion and absorption of fats and fat-soluble vitamins in the body. Bile acids are also inherently cytotoxic. They act as promoters of colon cancer, necrosis, and apoptosis. In humans, elevated levels of bile acids cause intrahepatic cholestasis of pregnancy, drug induced cholestasis, and chronic cholestatic liver disease. Thus the formation and elimination of bile acids must be tightly regulated. My current interest is to identify the various detoxification pathways involved in the elimination of these hydrophobic bile acids (esp. lithocholic acid).

Publications:

Deo AK and Bandiera SM (2008) Biotransformation of Lithocholic Acid by Rat Hepatic Microsomes: Metabolite Analysis by Liquid Chromatography/Mass Spectrometry. Drug Metab Dispos36:442-451. Deo AK and Bandiera SM (2008) Identification of Human Hepatic Cytochrome P450 Enzymes Involved in the Biotransformation of Cholic and Chenodeoxycholic Acid. Drug Metab Dispos. Singhania SS and Deo AK (2002) Monoclonal Antibody Technology: Trends and Prospects, Indian Journal of Pharmaceutical Sciences, 64: 20-26

Awards:

MERCK Student Scholarship