About the Scientist
Training
| Degree: |
Ph.D. in Chemical Engineering |
| Institution: |
McMaster University |
| Period: |
2009 |
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Previous Position
| Position: |
Ph.D. in Chemical Engineering |
| Research Group: |
McMaster University |
| Supervisors: |
2009 |
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Current Position
| Position: |
Postdoctoral Research Fellow |
| Supervisors: |
Dr. Helen Burt |
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Scholarships + Awards
| Name: |
Ontario Graduate Scholarship for Science and Technology |
| Period: |
2001/2008 |
|
|
| Name: |
1st place Henry I. Bolker Prize for the best oral presentation |
| Organization: |
92nd Annual Conference of Pulp and Paper Technical Association of Canada (PAPTAC) |
| Period: |
2006 |
|
|
| Name: |
1st place Alkis Karnis Memorial Prize for the best poster |
| Organization: |
Annual Conference of Pulp and Paper Technical Association of Canada (PAPTAC) |
| Tenure period: |
2006 |
|
|
| Name: |
Graduate Scholarship |
| Tenure period: |
2004-2008 |
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|
| Name: |
Graduate Tuition Bursary |
| Tenure period: |
2004-2006 |
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|
| Name: |
Graduate Entry Scholarship |
| Tenure period: |
2004 |
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|
| Name: |
Outstanding postgraduates (Beijing, China) |
| Tenure period: |
2002 |
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|
| Name: |
Outstanding M.Sc. Dissertation (Beijing, China) |
| Tenure period: |
2002 |
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About The Research
Current therapy of superficial bladder cancer involves the instillation of chemotherapy agents directly into the bladder after physical removal of the tumor tissues. However, the contact time of drugs with the bladder wall is very short, only ~2 hours due to voiding of urine, resulting in poor disease outcomes and high recurrence rates. Therefore there is a need for prolonging the contact time of drug delivery systems with the bladder wall. We believe that the modification of polymeric drug delivery nanoparticles with some mucoadhesive groups will enhance the binding of drug nanoparticles to the bladder tissues, prolong their contact time and increase the uptake of drugs into the tissue.
The hydrophobic anti-cancer agents, paclitaxel and docetaxel, and hydrophilic drug, cisplatin, have demonstrated significant efficacy in suppressing growth of bladder tumors. However, co-delivery of two anti-cancer drugs by a single drug delivery system still remains a challenge, due to the difficulty of developing a simple design and synthesis strategy for making pilot scale manufacture possible. Co-delivery systems possess the potential advantages of additive or synergistic effects, less drug resistance and the ability to provide different doses of the two drugs. We postulate that co-delivery will be possible using the nanoparticulate-forming, hyperbranched polyglycerols (HPG), hydrophobically modified to load paclitaxel in the core and functionalized on the outer shell with carboxylic acid groups to bind cisplatin. Furthermore, we believe that the charged carboxylate groups may confer mucoadhesive properties to the HPGs.
The overall goal of this proposal is to develop novel, multifunctional nano-sized polymeric drug delivery systems to achieve localized bladder mucosal drug delivery and co-delivery of two different chemotherapy agents. Our work will focus on the synthesis, modification, formulations development and selection, local tolerability and in vivo efficacy of formulations administered in animal models of superficial bladder cancer. We believe this research has the potential to lead to novel formulations with greater efficacy in treating superficial bladder cancer.
Publications + Presentations
| Patents |
- Brook, M. A., Brennan, J. D., Pelton, R. H., Voss, R., Ye, L., Biomolecule compatible silica particles, PCT Int. Appl. (2008), WO 2008061363 A1
- Li, X.; Ye, L.; Chen, D.; Bing, J. Surface treatment method for hydrophobic ability improvement of calcium carbonate nanoparticles, 2003, Chinese Patent: CN1462773
- Li, X.; Ye, L. Nano calcium carbonate-containing aqueous latex coating for inner wall and its production methods, 2003, Chinese Patent: CN1398932
- Li, X.; Ye, L. Nano calcium carbonate-containing aqueous latex coating for outer wall and its production methods, 2003, Chinese Patent: CN1398931
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| Papers |
- Ye, L.; Pelton, R. H.; Brook, M. A. Biotinylation of TiO2 nanoparticles and their conjugation with streptavidin. Langmuir 2007, 23, 5630-5637
- Ye, L.; Miao, C.; Brook, M. A.; Pelton, R. H. Photo-flocculation of TiO2 microgel mixed suspensions. Langmuir 2008, 24, 9341-9343
- Ye, L.; Filipe, C. D. M.; Kavoosi, M.; Haynes, C. A.; Pelton, R. H.; Brook, M. A. Immobilization of TiO2 nanoparticles onto paper modification through bioconjugation Journal of Materials Chemistry 2009, 19, 2189-2198
- Ye L.; Chen D. Q.; Liu J. Z.; Mao L. X.; Bing J. L.; Xie J.; Li X. Y. Influence of surface treatment on In-situ suspension polymerization of PVC/Nano-CaCO3 composite Zhongguo Suliao 2002, 16 (6), 39-43
- Ye L.; Gao Y.; Li X. Y. the modification of silk Silk 1999, 2, 24-27
- Ye, L.; Pelton, R. H., Filipe, C. D. M.; Wang H.; Brovko L.; Brook, M. A. Selective flocculation and killing of Escherichia coli with antibody coated TiO2, Langmuir, 2009, submitted
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| Conference presentations |
- Ye, L.; Filipe, C. D. M.; Brook, M. A.; Pelton, R. Targeted flocculation and killing of bacteria with antibody-TiO2 nanoparticles 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008
- Chen, Y.; Ye, L.; Yi, Y. Y.; Brennan, J.; Pelton R.; Brook M. A. Sol gel based titania monoliths: Surface modification for pathogen disinfection XIV International Sol-Gel Conference, Montpellier, France, September 2-7, 2007
- Ye, L.; Pelton, R.; Brook, M. Bio-conjunction of streptavidin on SiO2 and TiO2 particles 38th Central Regional Meeting of the American Chemical Society& 39th Silicon Symposium, Frankenmuth, MI, United States, May 16-20, 2006
- Ye L.; Brook, M.; Pelton R. A Platform of Immobilization of Proteins on TiO2 Nanoparticles (oral); Biotinylated TiO2 nanoparticles and their colloidal stability (poster) 92nd Annual Conference of Pulp and Paper Technical Association of Canada (PAPTAC), Montreal, Canada, February 6-10 2006
- Ye L.; Brook, M.; Pelton R. Biotinylation of TiO2 nanoparticles and their colloidal stabilities 55th Canadian Chemical Engineering Conference, Toronto, Canada, October 16-19 2005
- Ye L.; Brook, M.; Pelton R. Covalent attachment of biotin to TiO2 nanoparticles 79th ACS Colloid and Surface Science Symposium, Potsdam, NY, USA, June 12-15 2005
- Sentinel Conferences, Canada, 2005-2008 (twice per year) http://www.bioactivepaper.ca/
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