About the Students
Training
| Degree: |
M.S. in Biochemistry |
| Institution: |
California State University |
| Year: |
2008 |
|
| Degree: |
B.S. in Molecular Biology and Biochemistry |
| Institution: |
Simon Fraser University |
| Year: |
2004 |
|
Current Position
| Position: |
Ph.D. Student |
| Supervisor: |
Dr. H.M. Burt |
|
|
Scholarships + Awards
| Name: |
Graduate Dean’s List |
| Organization: |
California State University, Long Beach |
| Year: |
2008 |
|
|
| Name: |
Boeing Scholarship |
| Organization: |
California State University, Long Beach |
| Year: |
2008 |
|
|
| Name: |
Dr. Louise Perlgut Scholarship in Biochemistry for outstanding student |
| Organization: |
California State University, Long Beach |
| Year: |
2005 |
|
|
About The Research
Inhibition of Drug Efflux Transport Proteins by Amphiphilic Diblock Copolymers P-glycoprotein (Pgp), a transmembrane drug efflux transporter, is highly expressed in intestinal and blood brain barrier tissues and in multi-drug resistant (MDR) cancer cell lines, leading to a decrease in cellular drug absorption. Our preliminary study has indicated that a series of low molecular weight amphiphilic diblock copolymers based on methoxy poly (ethylene glycol) and poly (caprolactone), MePEG-b-PCL is capable of inhibiting Pgp function leading to increased cellular retention and therapeutic activity of drugs that are substrates of Pgp. The goal of the research is to design a diblock copolymer nanoparticulate delivery system that can modulate Pgp function leading to improved anticancer drug uptake and enhanced efficacy against MDR tumors.
Publications + Presentations
| Publications |
- Beckstead, J.A., Wong, K., Guta V., Wan, C.P., Cook, V.R., Weinberg, R.B., Weers, P.M., Ryan, R.O. 2007. "The C-terminus of apolipoprotein A-V modulates lipid binding activity" J. Biol. Chem. May 25;282(21):15484-9.
- Leon, L.J., Idangodage, H., Wan, C.P., and Weers, P.M. 2006. "Apolipophorin III: lipopolysaccharide binding requires helix bundle opening" Biochem. Biophys. Res. Commun. Oct 6;348(4):1328-33.
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