About the Students
Training
| Degree: |
Master's Pharmaceutical Sciences |
| Institution: |
Minia University, Egypt |
| Year: |
2005 |
|
| Degree: |
B. Pharm. Sci. |
| Institution: |
Alexandria University, Egypt |
| Year: |
1999 |
|
Current Position
| Position: |
Ph.D. Student |
| Supervisor: |
Dr. Kathleen MacLeod |
|
|
Research Projects
Rho-kinase in diabetic cardiomyopathy: cellular mechanisms underlying a novel treatment
Diabetic cardiomyopathy is characterized by systolic and diastolic dysfunction, independent of hypertension or ischemia. Currently, there is no specific drug available for its prevention or treatment. The cellular mechanisms underlying this condition have not been well elucidated but recently, our lab found that inhibition of the RhoA/Rho-kinase pathway led to complete recovery of contractile function in diabetic hearts, suggesting that this pathway plays a central role in diabetic cardiomyopathy. My project investigates the mechanisms by which inhibition of this pathway led to normalization of the contractile function of diabetic hearts.
Publications + Presentations
| Publications |
- Ismail HA, Khalifa MM, Hassan MK and Ashour OM, Insights in the mechanisms underlying the anti-ulcer activity of nicorandil. Pharmazie 2007; 62: 60-6.
- Ismail HA, Khalifa MM, Hassan MK and Ashour OM, Investigation of the mechanisms underlying the gastroprotective effect of nicorandil. Pharmacology 2007; 79: 76-85.
- Khalil H, Ismail H, Taye A and Kamel M, Gastroprotective effect of Lippia nodiflora L. extracts in ethanol-induced gastric lesions. Phcog Mag 2007; 3: 259-62.
- Craig G, Soliman H, Reddy Nagareddy P, Yuen V, Lin G, McNeill J and MacLeod K, Role of iNOS in Induction of RhoA Expression in Hearts from Diabetic Rats. Cardiovasc Res (submitted)
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| Books & Chapters |
- Ismail H. Pathophysiology of obesity and current treatment options. In Alternative approaches for the treatment of obesity, (2002), Motaal M and Ismail H, Alexandria, Eiman Press, 1-38.
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| Abstracts |
- Montasser M, Kassem M, Ashour O and Ismail H. Role of ATP-sensitive Potassium channels and selected chemical mediators as targets for the anti-ulcer activity of nicorandil in Rats. The 9th international Pharmaceutical Conference and Exhibition, King Saud University, Riyadh, KSA.
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