About the Students
Training
| Degree: |
M.Sc. in Chemical Sciences |
| Institution: |
Laurentian University |
| Year: |
2006 |
|
| Degree: |
B.Sc. in Biochemistry |
| Institution: |
Laurentian University |
| Year: |
2003 |
|
Current Position
| Position: |
Ph.D. Student |
| Supervisor: |
Dr. Helen Burt |
|
|
Scholarships + Awards
| Name: |
Graduate Internship |
| Organization: |
Merck-Frosst Canada Inc |
| Year: |
2008 |
|
|
| Name: |
Senior Graduate Studentship |
| Organization: |
Michael Smith Foundation for Health Research (MSFHR) |
| Year: |
2008 |
|
|
| Name: |
Postgraduate Scholarship D (PGS D) |
| Organization: |
Natural Sciences and Engineering Research Council of Canada (NSERC) |
| Year: |
2007 |
|
|
| Name: |
John H. McNeill Scholarship |
| Year: |
2006 |
|
|
| Name: |
Poster Award |
| Organization: |
Canadian College of Microbiologists |
| Year: |
2006 |
|
|
| Name: |
Tuition Fee Award |
| Organization: |
University of British Columbia |
| Year: |
2006 |
|
|
| Name: |
Graduate Entrance Scholarship |
| Organization: |
University of British Columbia |
| Year: |
2006 |
|
|
| Name: |
NSERC Research Capacity Building Grant, M.Sc. award |
| Year: |
2005 |
|
|
Research Projects
Development and characterization of intravesical mucoadhesive nanoparticulate formulations for postoperative chemotherapy in bladder cancer.
Urinary bladder cancer is one of the most commonly diagnosed malignancies in North America. The most common treatment method is transurethral resection followed by Intravesical chemotherapy which involves instillation of one or more chemotherapeutic agents into the bladder. However, the major limitation of this treatment is the rapid and almost complete washout of the drugs from the bladder on first void of urine, and low exposure of chemotherapeutic to tumor sites in the bladder wall, which ultimately leads to treatment failure. The goal of my research is to develop nanoparticulate formulations of drugs that are adhesive to the bladder wall, increase bladder tissue uptake and effective in treating bladder tumors.
Publications + Presentations
| Publications |
- C. Mugabe, B. Hadaschik, R.Kainthan, D. Brooks, A. So, M. Gleave, H. Burt (2008). Paclitaxel incorporated in hydrophobically derivatized hyperbranched polyglycerols for intravesical bladder cancer therapy. BJU Int. (Accepted).
- R. Kainthan, C. Mugabe, H. Burt, D. Brooks. (2008). Unimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols: ligand binding properties. Biomacromolecules 9, 886-895.
- M. Halwani, C. Mugabe, A. Azghani, R. Lafrenie, A. Kumar, A. Omri. (2007). Bactericidal Efficacy of Liposomal Aminoglycosides against Burkholderia cenocepacia. Journal of Antimicrobial Chemotherapy 60, 760-769.
- C. Mugabe, M. Halwani, A. Azghani, R. Lafrenie, A. Omri. (2006). Mechanism of Enhanced Activity of Liposome-entrapped Aminoglycosides against Resistant Strains of Pseudomonas aeruginosa. Antimicrobial Agents Chemotherapy 50, 2016-2022.
- C. Mugabe, A. Azghani, A. Omri. (2006). Preparation and Characterization of Dehydration-Rehydration Vesicles Loaded with Aminoglycoside and Macrolide Antibiotics. International Journal of Pharmaceutics 307, 244-250.
- G. Rukholm, C. Mugabe, A. Azghani, A. Omri. (2006). Antibacterial Activity of Liposomal Gentamicin against Pseudomonas aeruginosa: A Time-kill Study. International Journal of Antimicrobial Agents 27, 247-252.
- C. Mugabe, A. Azghani, A. Omri. (2005). Liposome-Mediated Gentamicin Delivery: Development and Activity against Resistant Strains of Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients. Journal of Antimicrobial Chemotherapy 55, 269-271.
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