Kangbin Zhou
About the Students
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Training
| Degree: | Bachelor of Science, Major Pharmacology 2009 (UBC) |
| Pharmacology Laboratory Skills: |
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| Biochemistry Laboratory Skills: |
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Current Position
| First year in Master of Science | Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences
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| Teaching Assistant | For:
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Scholarships + Awards
| Name: | President’s Entrance Scholarship |
| Year: | 2005 |
| Name: | J Fred Muir Memorial Scholarship in Science |
| Year: | 2007 |
| Name: | Science Scholar/Dean’s Honour List |
| Year: | 2006-2007 |
| Name: | Dean’s Honour List |
| Year: | 2007-2008 |
| Name: | Golden Key Membership |
| Year: | 2008 - present |
| Name: | Graduate Entrance Scholarship |
| Year: | 2009-2010 |
| Name: | International Partial Tuition Scholarship |
| Year: | 2009-2010 |
| Name: | Faculty of Pharmaceutical Sciences Graduate Award |
| Year: | 2009-2010 |
About the Research
The objective of the current research is to investigate the effects of phentolamine, a non-selective α adrenergic antagonist, on the hypertensive condition in fructose fed rats (FFRs). Wistar rats will be used as the model, which will be divided into four groups: control, control treated (with phentolamine), fructose fed, fructose fed treated. Plasma norepinephrine and angiotensin II level will be measured to evaluate the interaction between sympathetic nervous system (SNS) and rennin-angiontensin system (RAS).
These results will be compared to those obtained by a previous student Linda Tran who investigated the effects of prazosin, which is a α1 selective blocker, in order to indirectly evaluate the involvement of α2 receptors in hypertension. Insulin sensitivity will be measured and compared to that obtained by Tran, to validate the proposed relationship between β1 receptor activation and insulin resistance, since phentolamine, compared to prazosin, activates more β1 receptors. The direct measurement of α2 receptor activities in FFRs is currently being discussed. An in vitro study involving clonidine and yohimbine, a α2 selective agonist and antagonist, respectively, might be performed on blood vessels from FFRs to validate the current literature.
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