Claudio Erratico

About the Students

E-mail:

erratico@interchange.ubc.ca

Training

Name:	Bachelor’s Degree in Environmental Sciences
Institution:	Universita’ degli Studi di Milano-Bicocca (Milan, Italy).
Period:	September 1997-July 2004.

Name:	Research Thesis Project in Environmental Toxicology
Institution:	Syddansk Universitet, Odense campus, Denmark.
Supervisor:	Prof. Poul Bjerregaard.
Period:	March 2003-June 2004.

Name:	2-year Research Fellowship at National Research Council of Italy
Supervisor:	Dr. Luigi Viganò.
Period:	May 2005-May 2007.
Areas of research:	endocrine disruption in fish, bioaccumulation of organic pollutants in fish and invertebrates.

Name:	CO-OP Research Technician (Dr. Bandiera laboratory)
Institution:	The University of British Columbia.
Tenure period:	April-August 2008.
Areas:	gel electrophoresis for aromatase levels quantification and development of BDE-99 in vitro metabolism assay.

Current Position

PhD student in Dr. Bandiera laboratory (The University of British Columbia).

Scholarships + Awards

Name:	4-year Fellowship
Organization:	The University of British Columbia
Tenure period:	09-2010/09-2014
Value:	CAD$ 16,000/year

Name:	University Graduate Fellowship
Organization:	The University of British Columbia
Tenure period:	09-2009/09-2010
Value:	CAD$ 16,000

Name:	International Partial Tuition Scholarship
Organization:	The University of British Columbia
Tenure period:	09-2009/09-2010
Value:	CAD$ 3,100

Name:	Waters Limited Graduate Student Travel Award
Organization:	Waters Limited
Tenure period:	05-2009
Value:	CAD$ 750

Name:	International Partial Tuition Scholarship
Organization:	The University of British Columbia
Tenure period:	09-2008/09-2009
Value:	CAD$ 3,100

Name:	Graduate Entrance Scholarship
Organization:	The University of British Columbia
Tenure period:	09-2008
Value:	CAD$ 1,100

Name:	Graduate Fellowship
Organization:	Simon Fraser University
Tenure period:	09-2008/12-2008
Value:	CAD$ 6,250 (declined by me)

Name:	Research Fellowship
Organization:	National Research Council of Italy
Tenure period:	05-2005/05-2007
Value:	euro 34,000

About The Research

My project deals with the in vitro investigation of P450-mediated metabolism of BDE-99, a major polybrominated diphenyl ether (PBDE). The assay I developed to measured the formation of BDE-99 metabolites formed in vitro will be applied to rats (as animal models), humans, and wildlife species comprising a Pacific aquatic food chain (i.e. salmon, seals, killer whales, and polar bears). Knowledge regarding BDE-99 metabolism will provide insight into (i) which hydroxy metabolites and in what amounts humans and wildlife species are able to generate and therefore are exposed to; and (ii) which species are likely to be exposed to the highest metabolite-mediated toxicological risk. Toxicity of the metabolites will be investigated in the second part of my project.

Publications + Presentations

Publications

Viganò, L., Farkas, A., Guzzella, L., Roscioli, C., Erratico, C., 2007. The accumulation levels of PAHs, PCBs and DDTs are related in an inverse way to the size of a benthic amphipod (Echinogammarus stammeri Karaman) in the River Po. Sci. Total Environ. 373: 131-145.
Farkas, A., Erratico, C., Viganò, L., 2007. Assessment of the environmental significance of heavy metal pollution in surficial sediments of the River Po. Chemosphere 68 (4): 761-768.
Mandich, A., Benfenati, E., Bottero, S., Cevasco, A., Erratico, C., Maggioni, S., Massari, A., Pedemonte, F., Viganò, L., 2007. In vivo exposure of carp to graded concentrations of bisphenol A. Gen. Comp. Endocrinol. 153 (1-3): 15-24.
Viganò, L., Roscioli, C., Erratico, C., Guzzella, L., 2008. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in 0+ juvenile cyprinids and sediments of the Po river. Arch. Environ. Contam. Toxicol. 55(2): 282-94.
Viganò, L., Benfenati, E., van Cauwenberge, A., Eidem, J.K., Erratico, C., Goksøyr, A., Kloas, W., Maggioni, S., Mandich, A., Urbatzka, R., 2008. Estrogenicity profile and estrogenic compounds determined in river sediments by chemical analysis, ELISA, and yeast assays. Chemosphere 73: 1078-1089.
Bjerregaard, P., Hansen, P.R., Larsen, J.K., Erratico, C., Korsgaard, B., Holbech, H., 2008. Vitellogenin as a biomarker for estrogenic effects in brown trout, Salmo trutta: laboratory and field investigations. Environ. Toxicol. Chem. 27(11): 2387-2396.
Viganò, L., Roscioli, C., Erratico, C., Guzzella, L., Farkas, A., 2009. Polybrominated diphenyl ethers (PBDEs) in gammarids, caddiesflies, and bed sediments of the lowland River Po. Bull. Environ. Contam. Toxicol. 82(2): 200-205.
Erratico, C., Szeitz, A., Bandiera, S.M. Development and validation of a novel liquid chromatography-mass spectrometry method for the quantitation of hydroxylated metabolites of 2,2ʹ,4,4ʹ,5-pentabromodiphenylether (BDE-99) in rat liver microsomes. Chromat. B 878(19): 1562-1568.

Invited Presentations & Conference Abstracts

Erratico, C., Szeitz, A., Bandiera, S.M. Oxidative metabolism of BDE-99 in rat liver microsomes: validation of a novel in vitro assay using LC/MS. Analytical chemistry abstract No. 9, BFR2009: 11th Annual Workshop on Brominated Flame Retardants. International workshop held in Ottawa (Canada), May 2009.
Erratico, C., Bandiera, S.M. Oxidative metabolism of BDE-99 by rat liver microsomes: metabolites formed and CYP enzymes involved. Exposure and toxicology section, BFR 2010: International Symposium on Brominated Flame Retardants held in Kyoto (Japan), April 2010.
Erratico, C., Bandiera, S.M. In vitro metabolism of BDE-99 in human liver microsomes. Xenobiotic metabolism section, SOT 50th anniversary meeting held in Washington DC, March 2011.
Erratico, C., Bandiera, S.M. Oxidative metabolism of BDE-99 by rat liver microsomes and recombinant CYP enzymes. SETAC North America 31st Annual Meeting held in Portland (Oregon), November 2010.

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